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The distribution of pore sizes in a rock evolves continuously throughout its diagenetic history, strongly affecting flow and storage properties. One of the most important drivers of this evolution is mineral cementation, although existing models have not simultaneously represented the distinct effects of both carbonate and quartz cement within a single framework. Here we develop a modified population dynamics model that repres...
Chronological age is a common and non-modifiable factor for chronic disease, but does not fully explain age-related changes. Biological clocks have been developed to explore biological aging mechanisms. They could help identify protective factors against accelerated aging and associated diseases. We aim to assess the association between reduced epigenetic or inflammatory aging and ideal cardiovascular health or cardiovascular...
Disentangling the Effects of Biotic and Abiotic Dimensions of Ecological Opportunity on Individual Trophic Trait VariationNARA Subscribed
Within‐species individual trait variation (ITV) plays a critical role in ecological and evolutionary dynamics by influencing community structure, ecosystem functioning, and individual fitness. While the role of the biotic dimension of ecological opportunity (e.g., interspecific competition, prey availability) in shaping trophic ITV is now well established, the role of the abiotic dimension, and its interactions with biotic fac...
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of agingNARA Subscribed
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the “INStitute for Prevention” “healthy aging” and “medicine Rejuvenative” (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied...
Appetite loss is a common clinical condition in older adulthood, but how this condition associates with biological aging remains unknown. The present study aims to examine the associations of biological aging markers with appetite loss in community-dwelling people aged 21 to 102 years. This retrospective case–control study used baseline data from the INSPIRE-T cohort in Toulouse, France. Each of the 49 cases with appetite loss...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...