Growth-associated protein 43 (GAP43) is found in skeletal muscle, localized near the calcium release units. In interaction with calmodulin (CaM), it indirectly modulates the activity of dihydropyridine and ryanodine Ca 2+ channels. GAP43–CaM interaction plays a key role in intracellular Ca 2+ homeostasis and, consequently, in skeletal muscle activity. The control of intracellular Ca 2+ signaling is also an important functional...

Periodontitis is a common inflammatory disease that affects the teeth-supporting tissue and causes bone and tooth loss. Moreover, in a worldwide population, periodontal disease is often associated with cardiovascular diseases. Emerging studies have reported that one of the major pathogens related to periodontitis is Porphyromonas gingivalis ( P. gingivalis ), which triggers the inflammatory intracellular cascade. Here, we hypo...