Kutta is an indigenous sheep breed found in the mountainous region of Swat, Pakistan. In this study we evaluated the performance of Kutta sheep within their natural habitat and identified genomic regions associated with environmental adaptability using whole genome sequencing. Flocks are mostly managed under a transhumant production system with year-round breeding. Kutta sheep demonstrated higher lambing efficiency under the a...

Rationale Synthetic opioids like fentanyl are contributing to unprecedented overdose rates, yet the neural circuitry underlying fentanyl-associated behaviors remains poorly understood. The ventral tegmental area (VTA) projects to both the nucleus accumbens (NAc) and prefrontal cortex (PFC), forming distinct pathways that are implicated in drug-cue associations, though their specific roles in fentanyl-context encoding are not w...

Extreme heat is one of the fastest growing threats to human health, already causing tens of thousands of deaths annually and projected to affect hundreds of millions more people under continued warming. Australians are highly mobile and live in one of the most heat‐exposed countries, so rising temperatures create risks both at home and while travelling. Yet the implications of extreme heat for tourist health, behaviour and des...