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Plant Biotechnology Reports · 2025 · Vol. 19 · Issue 2 · Springer
Biosimilars produced in plant systems encompass a range of molecules, including antibodies, vaccines, enzymes, receptors, and other therapeutic molecules. In the present study, we aimed to express the immune checkpoint-inhibitor anti-CTLA-4 antibody, Ipilimumab, in Nicotiana tabacum plant. We generated transgenic tobacco plants using Agrobacterium -mediated transformation and purified an anti-CTLA-4 monoclonal antibody (mAb P...