Sophie Mathieu results 67
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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Global change is accelerating biological invasions, making it crucial to understand how species adapt in new environments to improve management strategies. Genomic data provide valuable insights into adaptation through genotype‐environment association (GEA) studies, which identify genes and biological processes tied to invasion success, and through geometric genomic offset (gGO) statistics, which estimate genetic (mal)adaptati...
Experimental Evidence for the Desynchronization of Ecosystem Dynamics by Global ChangeNARA Subscribed
Anticipating ecosystem responses to global change requires identifying the isolated and combined effects of environmental disturbance across both space and time. Examining the coordinated responses of ecosystems has recently emerged as a powerful approach to advance this understanding. We conducted two complementary experiments to identify whether, and if so how, warming temperatures, nutrient enrichment, predator overexploita...
Citizen science (also referred to as participatory science or community science), in which members of the general public contribute to scientific research, is not a new concept, as early examples of such studies can be found a couple of centuries ago. With the advancement of technology in an increasingly connected world, it has never been easier to engage citizen scientists in research projects. In this paper, we review citize...
The ocean plays an essential role in regulating Earth’s climate, influencing weather conditions, providing sustenance for large populations, moderating anthropogenic climate change, encompassing massive biodiversity, and sustaining the global economy. Human activities are changing the oceans, stressing ocean health, threatening the critical services the ocean provides to society, with significant consequences for human well-be...
Energy content has long been proposed as a fundamental, integrated, and reliable indicator of the condition of individuals as it reflects past bioenergetics and influences future life‐history traits. There is a direct biochemical link between energy density and body composition described by four main compounds in fish (protein, lipid, ash, and water), with proteins and lipids being the sources of energy. If relationships betwe...