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Springer Nature1
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Naunyn-Schmiedeberg's Archives of Pharmacology1
Publication Year
20261
Stanislava Stevanovic results 1 · Newest (Page 1/1, per page 25)
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The SGLT2 inhibitor empagliflozin promotes increased fatty acid oxidation in skeletal muscle cellsNARA Subscribed
Naunyn-Schmiedeberg's Archives of Pharmacology · 2026 · Vol. 399 · Issue 3 · Springer
Stanislava Stevanovic; Parmeshwar B. Katare; Hilde Mari Volledal; Hege G. Bakke; Klemen Dolinar; Sergej Pirkmajer; D. Margriet Ouwens; G. Hege Thoresen; Eili T. Kase; Arild C. Rustan
In this study we investigated the potential for the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) to modify energy metabolism in human primary skeletal muscle cells and mouse C2C12 skeletal muscle cells. The results showed that treatment of human myotubes with EMPA for 96 h decreased oxidation of exogenously added glucose and acetoacetate measured as CO 2 production, whereas CO 2 production from exogeno...
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