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VEGF and the VEGF73-101 Fragment Prevent MPP+ Induced Mitochondrial Dysfunction in a Cell Model of Parkinson’s DiseaseNARA Subscribed
Vascular endothelial growth factor (VEGF) is best known for its role in angiogenesis, but emerging evidence suggests neurotrophic and neuroprotective functions most likely connected to energy homeostasis pathways. Using high-resolution respirometry, we investigated the role of VEGF in optimizing mitochondrial oxidative phosphorylation efficiency in neuronal-like cells. Our findings indicate that VEGF enhances coupling efficien...
Purpose To describe the epidemiology, diagnosis, microbiological findings, clinical features, and outcomes of infectious spondylodiscitis (IS). Methods Retrospective analysis of 98 IS patients (2010–2023 - Trieste Hospital). Clinical, radiological, and microbiological data analysed, multivariate logistic regression assessed risk factors for poor outcomes. Results The incidence of IS was 3 cases per 100,000 inhabitants per year...
Ancient methane seep deposits exposed in the Apennine mountains of northern Italy are key to reconstruct the geodynamic evolution of the Miocene foredeep basin prior to the Messinian Salinity Crisis. Here, we report on a new Miocene outcrop of seep-carbonates in the Romagna region which showed indications of paleo-gas hydrate destabilization. We combined carbonate facies analyses, petrography of thin sections, scanning-electro...
Altitudinal variation of microplastic abundance in lakeshore sediments from Italian lakesNARA Subscribed
Microplastic (MP) contamination represents an issue of global concern for both aquatic and terrestrial ecosystems, but only in recent years, the study of MPs has been focused on freshwaters. Several monitoring surveys have detected the presence of a wide array of MPs differing in size, shape, and polymer composition in rivers and lakes worldwide. Because of their role of sink for plastic particles, the abundance of MPs was inv...
Autosomal dominant leukodystrophy (ADLD) is an ultra-rare, slowly progressive, and fatal neurodegenerative disorder associated with the loss of white matter in the central nervous system (CNS). Several years after its first clinical description, ADLD was found to be caused by coding and non-coding variants in the LMNB1 gene that cause its overexpression in at least the brain of patients. LMNB1 encodes for Lamin B1, a protein o...
Juvenile polyposis (JP) is a rare familial syndrome characterized by the development of numerous hamartomatous polyps of the gastrointestinal tract and by an increased risk of developing gastrointestinal cancers. It follows a pattern of autosomal dominant inheritance and is associated with germline variants of SMAD4 or BMPR1A genes. Differential diagnosis may be difficult based on histology alone, due to morphological similari...
El Niño teleconnection to the Euro-Mediterranean late-winter: the role of extratropical Pacific modulationNARA Subscribed
El Niño Southern Oscillation (ENSO) represents the major driver of interannual climate variability at global scale. Observational and model-based studies have fostered a long-standing debate on the shape and intensity of the ENSO influence over the Euro-Mediterranean sector. Indeed, the detection of this signal is strongly affected by the large internal variability that characterizes the atmospheric circulation in the North At...
Understanding the effects of environmental contaminants on honeybees is essential to minimize their impacts on these important pollinating insects. The aim of this study was to assess the ecotoxicological status of honeybees in environments undergoing different anthropic pressure: a wood (reference site), an orchard, an agricultural area, and an urban site, using a multi-biomarker approach. To synthetically represent the ecoto...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...