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In vitro models · 2026 · Springer
In the preclinical testing of novel drugs cell-based in vitro models can be used to replace animal testing. The cell line CI-pNaEC is a promising candidate for a suitable in vitro model of the nasal epithelium but suffers from low ciliation and inconsistent epithelial architecture. In this study, the influence of Notch and ROCK inhibition on differentiation benchmarks in CI-pNaEC was investigated. Ciliation was monitored via i...