Periodical cicada ( Magicicada spp.) ranges have continued to decline even as their habitat has rebounded from historic lows. This counterintuitive trajectory may be a consequence of Magicicada 's limited dispersal capabilities combined with their requirement that individual host trees survive across decades. Indeed, we find that the presence of Magicicada breeding populations is best predicted by tree cover in 1930, not by pr...

Supine-dependent OSA is a well-recognised OSA phenotype and may relate to craniofacial structure. Our aim was to assess whether craniofacial photos are able to identify positional OSA, specifically supine-isolated OSA, in comparison to non-positional OSA. Frontal and profile craniofacial photographs of participants were acquired according to a standardised protocol. Photographs were analysed and compared between non-positional...

Calcium carbonate production constitutes one of the core processes that drive coral reef ecosystem functioning and can be assessed using in-water or image-based survey methods, which have not previously been compared. This study compares carbonate production estimates from in-water ReefBudget surveys and image-based CoralNet analyses in Puerto Rico, Indonesia, and Chagos Archipelago. Methods were compared for different regions...

Erosion poses a significant threat to coastal and estuarine environments worldwide and is further exacerbated by anthropogenic activities and increasing coastal hazards. While conventional engineered structures, such as seawalls and revetments, are commonly employed to protect shorelines from wave impact and erosion, they can also cause detrimental environmental effects. By creating/restoring coastal habitats with engineered s...

The development of optimized dosing regimens plays a crucial role in oncology drug development. This study focused on the population pharmacokinetic modelling and simulation of docetaxel, comparing the pharmacokinetic exposure of oral docetaxel plus encequidar (oDox + E) with the standard of care intravenous (IV) docetaxel regimen. The aim was to evaluate the feasibility of oDox + E as a potential alternative to IV docetaxel....

The Pearl River Delta (PRD) region on the southeast coast of China is among the largest and most populated metropolitan regions of the world, subjecting the Indo-Pacific humpback dolphins ( Sousa chinensis ) inhabiting coastal waters of this region – apparently the largest population of this species – to intense anthropogenic pressure. In this 5-year study (2011-2015), we applied mark-recapture techniques to quantify populatio...

Rationale Clozapine is a unique medication with a potential role in the treatment of severe borderline personality disorder (BPD). Objectives The review examines the effectiveness of clozapine as a medication for management for severe BPD with high risk of suicide, violence or imprisonment, and aims to help guide clinical practice in managing severe BPD. Methods A database search of the terms “Clozapine” AND “BPD”; “Antipsycho...

Copy number variants (CNVs) represent major etiologic factors in rare genetic diseases. Current clinical CNV interpretation workflows require extensive back-and-forth with multiple tools and databases. This increases complexity and time burden, potentially resulting in missed genetic diagnoses. We present the Suite for CNV Interpretation and Prioritization (SCIP), a software package for the clinical interpretation of CNVs dete...