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Scaling of Short‐Duration, Summer Rainfall Event Temporal Profiles With Warming Over Great BritainNARA Subscribed
The relationship between extreme rainfall and temperature, known as temperature scaling, is widely used to understand changes in rainfall characteristics under a warming climate. While most previous studies have focussed on fixed‐duration intensities or event totals, this study examines how different aspects of the rainfall temporal profile respond to temperature. Specifically, we focus on temperature scaling of total event de...
In Vivo Clearance of Immune Complexes: Insights Into Human Drug/Anti-Drug Antibody Complex Clearance DynamicsNARA Subscribed
Immunogenicity of monoclonal antibodies (mAbs) and other biotherapeutics remains a significant clinical challenge. The resulting anti-drug antibodies (ADAs) can neutralize the drug, accelerate its clearance, diminish efficacy, and potentially trigger hypersensitivity reactions via the formation of immune complexes (ICs). Current pharmacokinetic (PK) and ADA assays typically measure the drug or ADAs but provide limited informat...
Atmospheric patterns associated with summer sub-daily rainfall extremes in western EuropeNARA Subscribed
Large-scale atmospheric circulations are a significant driver of rainfall extremes. However, little attention has so far been devoted to understanding how large-scale circulation patterns influence sub-daily rainfall extremes. Using a gauge-based sub-daily rainfall dataset, we investigate the relationship between large-scale circulations and 3-hour extremes (defined here as ≥ 40 mm rainfall in 3 h) for western Europe. A set of...
Feasibility of tracking invasive Escherichia coli disease among older adults in a community setting: A prospective observational studyNARA Subscribed
Purpose Invasive Escherichia coli disease (IED) encompasses a diverse range of sterile site infections. This study evaluated the feasibility of capturing IED among community-dwelling older adults to inform the implementation of a phase 3 efficacy trial of a novel vaccine against IED (NCT04899336). Methods EXPECT-1 (NCT04087681) was a prospective, multinational, observational study conducted in medically stable participants age...
ENSO and IOD contributions to seasonal meteorological droughts over the Yangtze River basinNARA Subscribed
The Yangtze River basin (YRB) has experienced frequent extreme drought events in recent years. Many studies have explored the impact of anomalous tropical sea surface temperatures on seasonal meteorological droughts over the YRB, yet two critical issues remain: (1) the regimes of the El Niño–Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) causing YRB droughts; (2) the timing and spatial pattern of YRB droughts caused...
The creation and climatology of a large independent rainfall event database for Great BritainNARA Subscribed
Extreme rainfall studies generally focus on hourly or daily rainfall accumulations. Additionally, studies focus on annual maxima (AM) or ‘peak intensities’. Although this approach is useful, the use of fixed‐duration accumulations simplifies inherently continuous rainfall processes which, at a rain gauge, are experienced as rainstorms of varying duration. A gap also exists in the study of sub‐hourly rainfall extremes which are...
Extensive regional variation in the phenology of insects and their response to temperature across N orth A mericaNARA Subscribed
Climate change models often assume similar responses to temperatures across the range of a species, but local adaptation or phenotypic plasticity can lead plants and animals to respond differently to temperature in different parts of their range. To date, there have been few tests of this assumption at the scale of continents, so it is unclear if this is a large‐scale problem. Here, we examined the assumption that insect taxa...
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states dur...
New hourly extreme precipitation regions and regional annual probability estimates for the UKNARA Subscribed
Recent flooding related to extreme precipitation in the UK has highlighted the importance of better understanding these events. Many studies have quantified annual exceedance probabilities (or return periods) for UK extreme daily precipitation using fixed regions (e.g., HadUKP) and region of interest (ROI) (e.g., Flood Estimation Handbook) approaches, although fewer have evaluated short‐duration events, which are important for...
Intense sub‐daily summer rainfall is linked to flooding impacts in the United Kingdom. Characterizing the atmospheric conditions prior to the rainfall event can improve understanding of the large‐scale mechanisms involved. The most intense sub‐daily rainfall intensity data generated from rain gauge records across the United Kingdom over the period 1979–2014 are combined with fields from the ERA Interim reanalysis to characteri...
Global distribution of the intensity and frequency of hourly precipitation and their responses to ENSONARA Subscribed
We investigate the global distribution of hourly precipitation and its connections with the El Niño–Southern Oscillation (ENSO) using both satellite precipitation estimates and the global sub-daily rainfall gauge dataset. Despite limited moisture availability over continental surfaces, we find that the highest mean and extreme hourly precipitation intensity (HPI) values are mainly located over continents rather than over ocean...
UKGrsHP: a UK high-resolution gauge–radar–satellite merged hourly precipitation analysis datasetNARA Subscribed
There is an urgent need for high-quality and high-spatial-resolution hourly precipitation products around the globe, including the UK. Although hourly precipitation products exist for the UK, these either contain large errors, or are insufficient in spatial resolution. An efficient way to solve this is to develop a merged precipitation product that combines the information and benefits from multiple data sources, improving bot...
Downscaling is usually necessary for robust hydrological impact assessments. This may be undertaken using a wide range of methods, including a combination of dynamical and statistical‐stochastic downscaling. This study uses the Spatial–Temporal Neyman‐Scott Rectangular Pulses model—RainSimV3, the precipitation‐conditioned daily weather generator—ICAAM‐WG, and the change factor approach for downscaling synthetic climate scenari...