H 2 O-undersaturated experiments and phase-equilibrium modelling demonstrate that orthopyroxene is the main ferromagnesian mineral formed during high-temperature crystallisation of most S-type and many I-type granitic (s.l.) magmas. In most examples, at any pressure relevant to crustal magmatism, orthopyroxene will be stable to T > 935 °C, in typical calc-alkaline metaluminous or peraluminous granitic magmas. Once such magmas...

One of the largest chromium deposits on Earth occurs in the Rustenburg Layered Suite (RLS) of the Bushveld Complex as laterally continuous chromitite layers. None of the hypotheses proposed for the origin of the chromitites can explain both the abundance of Cr in the RLS and the unusual enrichment in Cr and V over Ni, relative to typical depleted mantle values. This study investigates the possibility that the layering and chro...

Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological relationship to Parkinson’s disease (PD), and rapid progression have sparked interest in drug development. One significant obstacle to therapeutics is disease heterogeneity. Here, we share our process of developing a clin...

During each summer monsoon, the northeastern Indian Ocean receives a huge amount of rain and river discharge, resulting in strong stratification and prevalence of oligotrophic conditions. These water column changes impact upper ocean productivity which is reflected in the planktonic foraminifera distribution, providing an opportunity to study the effect of monsoon forcing and stratification history. Analogous to modern‐day str...