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Isatin–pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesteraseNARA Subscribed
Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....
Marine Isotope Stage 4 glaciation in northern England, UK: Evidence from Victoria Cave, North YorkshireNARA Subscribed
Victoria Cave, north Yorkshire, England, contains a long sequence of Pleistocene clastic sediments and calcite flowstones. Earlier work, using U–Th dating, established that the flowstone units formed in interglacial stages corresponding to Marine Isotope Stages (MIS) 13, 11, 9, 7 and 5. The intervening laminated sediments were therefore assigned to glacial stages (MIS 12, 10, 6 and 2) and regarded as rhythmites that settled fr...
The promise and pitfalls of monitoring harmful algal blooms (HABs) with remote sensing in pond-sized waterbodiesNARA Subscribed
Harmful algal blooms (HABs) pose water quality risks, including the depletion of dissolved oxygen and human health impacts. Remote sensing is a proven tool for monitoring HABs, yet knowledge is limited about its effectiveness in pond-sized waterbodies, whose size and shape may preclude multi-spectral platforms with large spatial resolutions and increase the probability of mixed pixels. This comparative limnology case study eva...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
This report provides an overview of the content and data collected from the “Successes, Challenges, and Opportunities Plant Transformation Research in Africa” panel discussion. Organized by PlantGENE, this event brought together scientists and stakeholders across the globe to examine the complex challenges and emerging opportunities in plant transformation research in laboratories across Africa. The discussion, rooted in insig...
The fundamental goal of a rare plant translocation is to create self‐sustaining populations with the evolutionary resilience to persist in the long term. Yet, most plant translocation syntheses focus on a few factors influencing short‐term benchmarks of success (e.g., survival and reproduction). Short‐term benchmarks can be misleading when trying to infer future growth and viability because the factors that promote establishme...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Expert range maps of global mammal distributions harmonised to three taxonomic authoritiesNARA Subscribed
Aim Comprehensive, global information on species' occurrences is an essential biodiversity variable and central to a range of applications in ecology, evolution, biogeography and conservation. Expert range maps often represent a species' only available distributional information and play an increasing role in conservation assessments and macroecology. We provide global range maps for the native ranges of all extant mammal spec...
Biodegradable, metal-chelating compounds as alternatives to EDTA for cultivation of marine microalgaeNARA Subscribed
Iron (Fe) is an essential nutrient for microalgal metabolism. The low solubility of Fe in oxic aquatic environments can be a growth-limiting factor for phytoplankton. Synthetic chelating agents, such as ethylenediaminetetraacetic acid (EDTA), are used widely to maintain Fe in solution for microalgal cultivation. The non-biodegradable nature of EDTA, combined with sub-optimal bioavailability of Fe-EDTA complexes to microalgae,...
The conduction velocity-potassium relationship in the heart is modulated by sodium and calciumNARA Subscribed
The relationship between cardiac conduction velocity (CV) and extracellular potassium (K + ) is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV. Recent studies from our group suggest that elevating extracellular sodium (Na + ) and calcium (Ca 2+ ) can enhance CV by an extracellular pathway parallel to gap junctional coupling (GJC) called ephaptic coupling that can occur in the gap junction a...