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Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer’s disease and related dementias in a community cohortNARA Subscribed
Hypertension in midlife is associated with increased dementia risk, yet its relationship with early pathological changes of Alzheimer’s disease and related dementias (ADRD) remains unclear. Unlike office blood pressure (BP), 24-h ambulatory BP (ABPM) may better reflect cardiovascular risk, but associations between 24-h BP measures with ADRD biomarkers are unknown. This cross-sectional study examined associations between BP and...
Comparison of three reanalysis‐driven regional climate models over New Zealand: Climatology and extreme eventsNARA Subscribed
Three ~12‐km reanalysis‐driven regional climate models (RCMs) are evaluated in terms of capturing climatologies and extremes of precipitation, temperature and surface wind over Aotearoa/New Zealand (NZ). NZ provides an excellent case study for evaluating high‐resolution RCMs due to its coastal and complex terrain and isolated geographical position in the midlatitudes, exposed to both tropical and polar influences. Overall, we...
Effective volcanic impact and risk assessment underpins effective volcanic disaster risk management. Yet contemporary volcanic risk assessments face a number of challenges, including delineating hazard and impact sequences, and identifying and quantifying systemic risks. A more holistic approach to impact assessment is required, which incorporates the complex, multi-hazard nature of volcanic eruptions and the dynamic nature of...
Lincosamide monotherapy treatment of methicillin-resistant Staphylococcus aureus pneumonia in tropical Australia: a case seriesNARA Subscribed
Existing recommended first-line antibiotic agents for MRSA pneumonia have several shortcomings. We reviewed 29 cases of community- and hospital-acquired MRSA pneumonia managed at our hospital. Lincosamide monotherapy was administered to 21/29 (72%) and was the predominant antibiotic regimen (> 50% course duration) in 19/29 (66%). Patients receiving lincosamide-predominant monotherapy were no more likely to die or require inten...
Understanding the relative effectiveness and enabling conditions of different area‐based management tools is essential for supporting efforts that achieve positive biodiversity outcomes as area‐based conservation coverage increases to meet newly set international targets. We used data from a coastal social–ecological monitoring program in 6 Indo‐Pacific countries to analyze whether social, ecological, and economic objectives a...
Particle showers detected on ISS in Timepix pixel detectorsNARA Subscribed
Life in the fast lane: Revisiting the fast growth—High survival paradigm during the early life stages of fishesNARA Subscribed
Early life survival is critical to successful replenishment of fish populations, and hypotheses developed under the Growth‐Survival Paradigm (GSP) have guided investigations of controlling processes. The GSP postulates that recruitment depends on growth and mortality rates during early life stages, as well as their duration, after which the mortality declines substantially. The GSP predicts a shift in the frequency distributio...
Pollinating insects are declining due to habitat loss and climate change, and cities with limited habitat and floral resources may be particularly vulnerable. The effects of urban landscapes on pollination networks remain poorly understood, and comparative studies of taxa with divergent niches are lacking. Here, for the first time, we simultaneously compare nocturnal moth and diurnal bee pollen‐transport networks using DNA met...
Integrating larval connectivity into the marine conservation decision‐making process across spatial scalesNARA Subscribed
Larval dispersal connectivity is typically integrated into spatial conservation decisions at regional or national scales, but implementing agencies struggle with translating these methods to local scales. We used larval dispersal connectivity at regional (hundreds of kilometers) and local (tens of kilometers) scales to aid in design of networks of no‐take reserves in Southeast Sulawesi, Indonesia. We used Marxan with Connectiv...
Comparing spatial conservation prioritization methods with site‐ versus spatial dependency‐based connectivityNARA Subscribed
Larval dispersal is an important component of marine reserve networks. Two conceptually different approaches to incorporate dispersal connectivity into spatial planning of these networks exist, and it is an open question as to when either is most appropriate. Candidate reserve sites can be selected individually based on local properties of connectivity or on a spatial dependency‐based approach of selecting clusters of strongly...
Spatial compositional turnover varies with trophic level and body size in marine assemblages of micro‐ and macroorganismsNARA Subscribed
Aim Spatial compositional turnover varies considerably among co‐occurring assemblages of organisms, presumably shaped by common processes related to species traits. We investigated patterns of spatial turnover in a diverse set of marine assemblages using zeta diversity, which extends traditional pairwise measures of turnover to capture the roles of both rare and common species in shaping assemblage turnover. We tested the gene...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Despite increasing recognition of the need for more diverse and equitable representation in the sciences, it is unclear whether measurable progress has been made. Here, we examine trends in authorship in coral reef science from 1,677 articles published over the past 16 years (2003–2018) and find that while representation of authors that are women (from 18 to 33%) and from non-OECD nations (from 4 to 13%) have increased over ti...
Marine heatwaves are increasing in frequency and intensity, and indirectly impacting coral reef fisheries through bleaching‐induced degradation of live coral habitats. Marine heatwaves also affect fish metabolism and catchability, but such direct effects of elevated temperatures on reef fisheries are largely unknown. We investigated direct and indirect effects of the devastating 2016 marine heatwave on the largest reef fishery...
Small‐scale fisheries are an important livelihood and primary protein source for coastal communities in many of the poorest regions in the world, yet many are overfished and thus require effective and scalable management solutions. Positive ecological and socioeconomic responses to management typically lag behind immediate costs borne by fishers from fishing pressure reductions necessary for fisheries recovery. These short‐ter...