Biallelic mutations in multiple EGF domain protein 10 ( MEGF10 ) gene cause EMARDD (early myopathy, areflexia, respiratory distress and dysphagia) in humans, a severe recessive myopathy, associated with reduced numbers of PAX7 positive satellite cells. To better understand the role of MEGF10 in satellite cells, we overexpressed human MEGF10 in mouse H-2k b -tsA58 myoblasts and found that it inhibited fusion. Addition of purifi...