Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME), highlighting the importance of immunotherapeutic targeting of gene mutations in governing tumor progression. TP53 is a prominent tumor suppressor that encodes the p53 protein, which controls the initiation and progression of different tumor types. Wild-type p53 maintains cell homeostasi...

Rising sea level caused by global climate change may increase extreme sea level events, flood low-lying coastal areas, change the ecological and hydrological environment of coastal areas, and bring severe challenges to the survival and development of coastal cities. Hong Kong is a typical economically and socially developed coastal area. However, in such an important coastal city, the mechanisms of local sea-level dynamics and...