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Marine macroalgae play an important yet underrecognized role in coastal and benthic carbon cycling, with recent attention focusing on their contribution to blue carbon storage via detrital pathways. However, their ecological significance remains underrepresented in molecular monitoring studies, partly due to the absence of dedicated genetic markers for sedimentary detection. Here, we developed and validated a novel environment...
Generation of NOD SCID mice with near-complete deletions of Il2rg and Prkdc for human cancer and HSC engraftmentNARA Subscribed
Immunodeficient mouse models are invaluable tools for preclinical research, particularly for cancer therapies and studies of the human immune system. Notably, strains with combined Prkdc (scid) and Il2rg (null) mutations—such as NOG and NSG mice— are widely used due to their profound immunodeficiency, allowing efficient engraftment of various human cells. However, these models were generated by disrupting the Il2rg gene throug...
Copper–zinc imbalance induces kidney tubule damage and oxidative stress in a population exposed to chronic environmental cadmiumNARA Subscribed
Purpose This cross-sectional study aimed to assess the effect of environmental cadmium (Cd) exposure and essential metal imbalance on renal tubular damage and oxidative stress in 979 adults living in a Cd-polluted area near an abandoned copper (Cu) refinery. Methods We analyzed urinary Cd concentrations, renal tubular damage and oxidative stress markers, such as beta-2 microglobulin (β2-MG) and N -acetyl-β- d -glucosaminidase...