Chromosomal inversion polymorphisms are ubiquitous across the diversity of diploid organisms and play a significant role in the evolution of adaptations in those species. Inversions are thought to operate as supergenes by trapping adaptive alleles at multiple linked loci through the suppression of recombination. While there is now considerable support for the supergene mechanism of inversion evolution, the extent to which inve...

The ~75 ka Young Toba super‐eruption was a catastrophic extreme event that spewed vast quantities of volcanic ash and aerosols and is argued to have caused a drastic volcanic winter, climatic upheaval, and a human genetic bottleneck. The global and regional impacts of the eruption on climate dynamics and past hominin populations are strongly contested due to conflicting global climatic records and archeological datasets. The I...

Breast cancer is a common form of cancer that affects both men and women. One of the most common types of genomic flaws in cancer is the aberrations in the PI3K/AKT/mTOR pathway. The benefit of dual targeting PI3K as well as mTOR is that the kinase-positive feedback loops are more effectively inhibited. Therefore, in the current study, structure-based models like molecular docking, MM-GBSA, Qikprop, induced fit docking, simula...

Cyprinid herpesvirus‐3 (CyHV‐3) is an important pathogen of common carp ( Cyprinus carpio , carp) causing significant economic and ecological impacts worldwide. The recent emergence of CyHV‐3 in the Upper Midwest region of the United States has raised questions related to the disease ecology and host specificity of CyHV‐3 in wild carp populations. To determine the prevalence of CyHV‐3 in wild populations of fishes in Minnesota...