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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Summary Trichoderma arundinaceum (Ta37) and Botrytis cinerea (B05.10) produce the sesquiterpenoids harzianum A (HA) and botrydial (BOT), respectively. TaΔTri5, an HA non‐producer mutant, produces high levels of the polyketide compounds aspinolides (Asp) B and C. We analyzed the role of HA and Asp in the B. cinerea ‐ T. arundinaceum interaction, including changes in BOT production as well as transcriptomic changes of BcBOT gene...
New tricks of an old enemy: isolates of F usarium graminearum produce a type A trichothecene mycotoxinNARA Subscribed
Summary The ubiquitous filamentous fungus F usarium graminearum causes the important disease F usarium head blight on various species of cereals, leading to contamination of grains with mycotoxins. In a survey of F . graminearum ( sensu stricto ) on wheat in N orth A merica several novel strains were isolated, which produced none of the known trichothecene mycotoxins despite causing normal disease symptoms. In rice cultures, a...
Production of trichodiene by T richoderma harzianum alters the perception of this biocontrol strain by plants and antagonized fungiNARA Subscribed
Summary Trichothecenes are phytotoxic sesquiterpenic mycotoxins that can act as virulence factors in plant diseases. H arzianum A ( HA ) is a non‐phytotoxic trichothecene produced by T richoderma arundinaceum . The first step in HA biosynthesis is the conversion of farnesyl diphosphate to trichodiene ( TD ), a volatile organic compound ( VOC ), catalysed by a sesquiterpene synthase encoded by the tri5 gene. Expression of tri5...
Summary H arzianum A ( HA ), a trichothecene produced by T richoderma arundinaceum , has recently been described to have antagonistic activity against fungal plant pathogens and to induce plant defence genes. In the present work, we have shown that a tri5 gene‐disrupted mutant that lacks HA production overproduces two polyketides, aspinolides B and C , which were not detected in the wild‐type strain. Furthermore, four new aspi...
Microbial Detoxification of MycotoxinsNARA Subscribed
Biological activity of FGF-23 fragmentsNARA Subscribed
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