The goal of developing interventions to slow ageing is not only lifespan extension but more importantly to increase healthspan, the period of life spent in active good health. Nutritional interventions have emerged as a potential strategy to maintain health with age. Testing these interventions for effects on human ageing would take several years and require large cohort sizes. We therefore employed C. elegans as a rapidly age...

The increasing demand for accurate toxicity assessment and to minimise or eliminate the use of animal testing has accelerated the development of numerous computational models, AI/ML models, and online resources that support research in computational toxicology. This review addresses toxicity prediction and chemical safety evaluation, focusing on computational models and data coverage, Molecular Descriptors, QSAR models, AI/ML-...

The status of many shark species worldwide is concerning due to a combination of their life-history traits and widespread exposure to threats, especially fishing. However, the intrinsic vulnerability of species differ given that life-history traits vary with environmental conditions. Here, we aim to assess the links between sharks’ reproductive strategy, maximum depth recorded, and environment occupied (shelf, deepwater and pe...