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The multi-drug combination regime, FOLFIRINOX, is a standard of care chemotherapeutic therapy for pancreatic cancer patients. However, systematic evaluation of potential pharmacodynamic interactions among multi-drug therapy has not been reported previously. Here, pharmacodynamic interactions of the FOLFIRINOX agents (5-fluorouracil (5-FU), oxaliplatin (Oxa) and SN-38, the active metabolite of irinotecan) were assessed across a...
Abiotic and Biotic Factors Affecting Loblolly Pine Health in the Southeastern United StatesNARA Subscribed
Southern pine forests are important fiber and wood sources, and critical to local, regional, and national economies in the United States. Recently, certain areas of southern pine forests, especially those dominated by loblolly pine (Pinus taeda), have been reported to exhibit abnormally high levels of tree dieback and mortality. However, causal agents either have not been well defined or are controversial in their impacts on t...
Seasonality in surface‐layer net zooplankton communities in Prince William Sound, AlaskaNARA Subscribed
The upper‐layer net‐zooplankton community in Prince William Sound, Alaska, is characterized by strong seasonality. Abundance and wet‐weight biomass in the upper 50 m drop to fewer than 100 individuals and 10 mg m −3 in February before rebounding to 5000 individuals and 600 mg m −3 in June. Copepods dominate in all months, but are augmented by other prominent taxa, particularly pteropods and larvaceans during the late spring, s...
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