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Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbationsNARA Subscribed
Acute respiratory exacerbations in bronchiectasis are important as they impair quality of life and are associated with accelerated lung function decline. Yet, no validated methods exist to identify children at increased risk of exacerbations. We therefore determined if peripheral blood gene expression (GE) signatures can identify those at risk of an impending exacerbation. Thirty-one children with bronchiectasis had RNA extrac...
Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research SocietyNARA Subscribed
Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...
Between 1989 and 2007, 28 Distinct Population Segments (DPS) of Pacific salmon ( Oncorhynchus spp.) spawning in rivers in California and the Pacific Northwest (Oregon, Washington, Idaho) were listed (protected) under the US Endangered Species Act (ESA). In the roughly 25 years since then, considerable efforts have been made to recover these populations, but no DPS has increased sufficiently to be delisted. We evaluated abundan...
Trait‐based approaches to study biodiversity responses to changing environmental conditions have become popular because these approaches provide context to how and why certain taxa shift in abundance within an assemblage. Trait‐based approaches also offer the potential to link shifts in assemblage composition to effects on ecosystem functions like rates of primary production, detrital decomposition, and nutrient uptake. Howeve...
Evidence of the need for crop-specific N2O emission factorsNARA Subscribed
Importance of timely metadata curation to the global surveillance of genetic diversityNARA Subscribed
Genetic diversity within species represents a fundamental yet underappreciated level of biodiversity. Because genetic diversity can indicate species resilience to changing climate, its measurement is relevant to many national and global conservation policy targets. Many studies produce large amounts of genome‐scale genetic diversity data for wild populations, but most (87%) do not include the associated spatial and temporal me...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Opposing macroevolutionary and trait‐mediated patterns of threat and naturalisation in flowering plantsNARA Subscribed
Due to expanding global trade and movement of people, new plant species are establishing in exotic ranges at increasing rates while the number of native species facing extinction from multiple threats grows. Yet, how species losses and gains globally may, together, be linked to traits and macroevolutionary processes is poorly understood. Here, we show that, adjusting for diversification rate and clade age, the proportion of th...
Eleven viral haemorrhagic septicaemia virus (VHSV) genotype IVb isolates were sequenced, and their genetic variation explored to determine the source of a VHS outbreak on the eastern shore of Cayuga Lake. An active fish kill of round gobies ( Neogobius melanostomus , Pallas) was intensively sampled at King Ferry, NY and nearby Long Point State Park in May 2017. Gross lesions observed on 67 moribund round gobies and two rock ba...