Alzheimer’s disease (AD) is a progressive age-dependent neurodegenerative disorder associated with oxidative brain damage, disrupted neuronal transmission, memory loss, and behavioral changes, with aluminum being a key environmental risk factor that exacerbates its effect. The aim of this study is to enhance the therapeutic potential of astaxanthin (AST) in Alzheimer’s disease by formulating it into invasomal carriers, with sp...

Background Vascular calcification (VC) is a major predictor of cardiovascular diseases that represent the principal cause of mortality among type-2 diabetic patients. Accumulating data suggest the vital role of some microRNAs on vascular calcification as an epigenetic regulator. Thus, we assessed herein, the role of serum miR-433-3p in vascular calcification in type-2 diabetic patients. Methods Twenty healthy subjects (control...

Growing evidence supports the role of the gut-kidney axis and persistent mitochondrial dysfunction in the pathogenesis of diabetic nephropathy (DN). Ulinastatin (UTI) has a potent anti-inflammatory effect, protecting the kidney and the gut barrier in sepsis, but its effect on DN has yet to be investigated. This study aimed to assess the potential mitigating effect of UTI on DN and investigate the possible involvement of gut-ki...