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Isatin–pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesteraseNARA Subscribed
Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....
Accelerated breeding modernization: a global blueprint for driving genetic gains, climate resilience, and food security in riceNARA Subscribed
Key message ABM-BOx is a mission-critical transformation engine, built to fast-track genetic gains, boost climate resilience, and modernize outdated breeding programs into agile, data-driven, demand-responsive innovation platforms setting a global benchmark. Abstract Rice plays a central role in global food security as climate threats continue to rise. Fast-tracking genetic gains and developing climate-resilient, market-prefer...