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Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochleaNARA Subscribed
Pathogenic variation of SLC26A 4 gene causes both Pendred syndrome (PDS) and non-syndromic enlarged vestibular aqueduct (NSEVA/DFNB4), two autosomal recessive disorders. The former accounts for approximately 6% of human genetic hearing loss, making it the second most common form of syndromic deafness after Usher syndrome, while the latter is the most common radiological malformation associated with childhood sensorineural hear...
We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...
Patients receiving chemotherapy for cancer treatment may develop chemotherapy-induced peripheral neuropathy (CIPN), a type of neuropathic (nerve) pain that is often difficult to treat. First-line analgesic/adjuvant agents recommended for the treatment of neuropathic pain often lack efficacy and/or evoke dose-limiting side-effects in patients with CIPN. Hence, there is a large unmet medical need for novel, well-tolerated analge...
Drought on the Fly: UAS Mapping of Conifer Drought StressNARA Subscribed
Foliar moisture content (FMC) plays a crucial role in arid, frequent-fire forests by influencing fire behavior, tree survival, and serving as a proxy for tree health. Management actions such as mechanical thinning, flammable fuels reduction, and prescribed fires can act to mitigate wildfire risk and improve forest health by reducing fuel connectivity, diversifying forest structure, and creating canopy gaps. These management ac...
Mercury (Hg), and specifically methylmercury (MeHg), is a contaminant of global concern to humans and wildlife, but there is still limited understanding of its effects on many taxa. Amphibians are closely associated with water, where Hg is converted to MeHg, and high concentrations of MeHg can reduce survival of amphibians in the wild. However, limited non-lethal proxies exist for estimating MeHg bioaccumulation in amphibian l...
Nutrient Enrichment Increases Grassland Biomass Sensitivity to Interannual Precipitation VariationNARA Subscribed
Primary production underpins much of ecosystem functioning and is often limited by nutrient and water availability. Ongoing global increases in nutrient inputs and interannual precipitation variability are thus likely to impact primary production, with unclear consequences for interannual variability in plant biomass. We used data from 35 grasslands in the Nutrient Network coordinated fertilization experiment to test if nutrie...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...