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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alternative Future Vegetation Pathways Reveal Potential Transformations of Western US EcosystemsNARA Subscribed
Managing ecosystems in an era of rapid change is inherently challenging not only because of uncertainty in future climate but also due to diverse responses of ecosystems to climate. Projections of ecological transformation alongside information about plausible vegetation trajectories can help land managers explore divergent scenarios and consider how modeled outcomes match their observations. Climate‐analog impact models (AIMs...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
DEK Loss Induces Task-specific Deficits in Learning and Memory and Reprograms the Hippocampal Transcriptome in MiceNARA Subscribed
DEK is an estrogen-responsive chromatin-remodeling protein broadly expressed in the murine and human brain, with high expression in memory-relevant regions such as the hippocampus. Prior work from our group and others has linked DEK loss to cellular features associated with Alzheimer’s disease and Alzheimer’s disease-related dementias. Notably, our group has demonstrated that DEK expression declines with increasing dementia se...