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Isatin–pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesteraseNARA Subscribed
Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....
Climate Attribution in Fishery Stock Assessment: Case Studies From the Northeast U.S. Groundfish StocksNARA Subscribed
Climate change poses an unprecedented risk to fisheries ecosystems and economies globally. Ocean warming has led to observed geographic shifts and changes in the productivity of fish stocks. Due to the rapid pace of change in many of the world's oceans, there is a critical need to develop and apply scientific knowledge and tools that can help account for non‐stationarity and integrate climate and ecosystem drivers into fishery...
Drought on the Fly: UAS Mapping of Conifer Drought StressNARA Subscribed
Foliar moisture content (FMC) plays a crucial role in arid, frequent-fire forests by influencing fire behavior, tree survival, and serving as a proxy for tree health. Management actions such as mechanical thinning, flammable fuels reduction, and prescribed fires can act to mitigate wildfire risk and improve forest health by reducing fuel connectivity, diversifying forest structure, and creating canopy gaps. These management ac...
Radiopaque microsphere-hydrogel composite for extended-release intratumoral immunotherapy in a large animal modelNARA Subscribed
Intratumoral injection of immune stimulants could potentially reverse the immunosuppressive tumor microenvironment, but the injected drug rapidly washes out into the systemic circulation. This results in systemic toxicity, and reduced efficacy, potentially requiring daily injections to generate an antitumor immune response. To address this problem, we developed an extended-release hydrogel that retains the immunotherapy agent...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...