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Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochleaNARA Subscribed
Pathogenic variation of SLC26A 4 gene causes both Pendred syndrome (PDS) and non-syndromic enlarged vestibular aqueduct (NSEVA/DFNB4), two autosomal recessive disorders. The former accounts for approximately 6% of human genetic hearing loss, making it the second most common form of syndromic deafness after Usher syndrome, while the latter is the most common radiological malformation associated with childhood sensorineural hear...
An assessment of ocean thermal energy conversion resources and climate change mitigation potentialNARA Subscribed
Ocean thermal energy conversion (OTEC) is a renewable energy system that harnesses the thermal gradient between surface and deep waters. Many multi-century simulations with a fully coupled climate-carbon cycle model are presented to explore the amount of extractable energy and the climate change mitigation potential from the widespread implementation of OTEC. The sustainability of OTEC power generation was assessed for present...
Environmental impacts from the widespread implementation of ocean thermal energy conversionNARA Subscribed
Ocean thermal energy conversion (OTEC) is a renewable energy system that could potentially displace significant amounts of fossil fuel-generated electricity. This study presents numerous multi-century simulations of the University of Victoria Earth System Climate Model, a coupled climate-carbon cycle model, to better understand the global-scale environmental impacts of the widespread implementation of OTEC at varying total pow...
Microplastics (MPs) are known vectors for the transport of pathogens and antibiotic resistance genes (ARGs), but few studies have examined the long‐term (> 30 days) development of MP biofilms. Wastewater Treatment Plant (WWTP) effluents are a significant source of MPs, pathogens, and antibiotics released into the environment. We explored the development of biofilms on high‐ and low‐density polyethylene, polypropylene, and poly...
Groundwater is a hidden global keystone ecosystemNARA Subscribed
Groundwater is a vital ecosystem of the global water cycle, hosting unique biodiversity and providing essential services to societies. Despite being the largest unfrozen freshwater resource, in a period of depletion by extraction and pollution, groundwater environments have been repeatedly overlooked in global biodiversity conservation agendas. Disregarding the importance of groundwater as an ecosystem ignores its critical rol...
Response of the plant core microbiome to Fusarium oxysporum infection and identification of the pathobiomeNARA Subscribed
Plant core microbiomes consist of persistent key members that provide critical host functions, but their assemblages can be interrupted by biotic and abiotic stresses. The pathobiome is comprised of dynamic microbial interactions in response to disease status of the host. Hence, identifying variation in the core microbiome and pathobiome can significantly advance our understanding of microbial–microbial interactions and conseq...
Efficiency in storm surge modeling is crucial for forecasting coastal hazards in real-time. While computation cost may not be the main concern for organizations with ample resources, the robustness of forecasts generated by most parties are restricted by wall-clock time. The Parametric Wave Solver (PARAM) was developed by Boyd and Weaver (2021) as an alternative to computationally expensive wind–wave models when modeling restr...
Like many estuaries worldwide, the Indian River Lagoon (IRL), has seen a decline in resources and overall water quality due to human activities. One method to help restore water quality and benthic habitats is to construct and deploy oyster restoration mats on dock pilings, known as the Living Docks program. This community-driven program was founded to promote the growth of filter-feeding benthic organisms and improve local wa...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Marine conservation design and fisheries management are increasingly integrating biophysical, socio-economic and governance considerations. Integrative approaches are adopted to achieve more effective, equitable, inclusive, and robust marine policies and practices. This paper describes a participatory process to co-produce biophysical, socio-economic, and governance principles to guide the design and management of marine reser...