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Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal ClodronateNARA Subscribed
BACKGROUND : The use of mouse bone marrow mesenchymal stem cells (mBMSCs) represents a promising strategy for performing preclinical studies in the field of cell-based regenerative medicine; however, mBMSCs obtained via conventional isolation methods have two drawbacks, i.e., (i) they are heterogeneous due to frequent macrophage contamination, and (ii) they require long-term culturing for expansion. METHODS : In the present st...