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Naunyn-Schmiedeberg's Archives of Pharmacology · 2026 · Vol. 399 · Issue 10 · Springer
The antihypertensive effects of nitrate and nitrite are widely described. Likewise, the physiological relevance of the nitrate-nitrite-nitric Oxide (NO) cycle in cardiovascular homeostasis is well known. Nevertheless, the mechanisms underlying the effects of nitrite are not completely understood, particularly in relation to S-nitrosothiol formation. On the other hand, the angiotensin-converting enzyme (ACE) plays a central rol...