Terry Roberts results 135
· Newest (Page 1/6, per page 25)
Author: Terry Roberts ×Clear All Filters
Search Results
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityNARA Subscribed
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases. Therefore, telomeres are considered to be one of the biomarkers of aging, and increasing or maintaining telomere length may contribute to heal...
Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of concept pilot studyNARA Subscribed
Rapamycin (RAPA) and related mTOR-inhibitors have been shown to enhance healthy aging in animal models (2–10) and to be generally safe and tolerable in older people (11–13). However, studies to assess their effects on specific age-related pathologies in humans are limited. Since improvements in cardiovascular function with RAPA treatment have been reported in preclinical studies (5, 9, 10, 14–17), we posited that RAPA could be...
New Approach Needed To Address Declining Forestry Research Capacity And Relevancy in the US: A Call-To-ActionNARA Subscribed
Recent dramatic reductions in research funding and personnel for university and government organizations by the new federal administration will reduce forestry research capacity in the coming years. However, these cuts only highlight the long-standing decline in forestry research capacity that has been occurring over the past several decades. These reductions will continue to impair the country’s ability to meet the scale and...
AviList: a unified global bird checklistNARA Subscribed
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Endocrine-disrupting contaminants (EDCs) are frequently monitored in environments because of their biological impacts on wildlife and humans. We conducted a systematic review using Web of Science to identify global research trends for EDC environmental sampling. Specifically, we aim to better understand geographic variation in (1) the compartment that EDCs were sampled in the environment; (2) the types of EDC sampled; and (3)...
Wind dispersed tree species have greater maximum heightNARA Subscribed
Aim We test the hypothesis that wind dispersal is more common among emergent tree species given that being tall increases the likelihood of effective seed dispersal. Location Americas, Africa and the Asia‐Pacific. Time period 1970–2020. Major taxa studied Gymnosperms and Angiosperms. Methods We used a dataset consisting of tree inventories from 2821 plots across three biogeographic regions (Americas, Africa and Asia‐Pacific),...
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disordersNARA Subscribed
Rationale Medications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities that drive opioid abuse and relapse. ITI-333 is a novel molecule in development for treatment of substance use disorders, psychiatric comorbidities, and pain. Objective Characterize the preclinical profile of ITI-333 using pharmacological, behavioral, and physiological assays. Methods Cell-based a...
Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic TherapeuticsNARA Subscribed
The identification and removal of host cell proteins (HCPs) from biologic products is a critical step in drug development. Despite recent improvements to purification processes, biologics such as monoclonal antibodies, enzyme replacement therapies, and vaccines that are manufactured in a range of cell lines and purified using diverse processes may contain HCP impurities, making it necessary for developers to identify and quant...
Assessing variants of uncertain significance implicated in hearing loss using a comprehensive deafness proteomeNARA Subscribed
Hearing loss is the leading sensory deficit, affecting ~ 5% of the population. It exhibits remarkable heterogeneity across 223 genes with 6328 pathogenic missense variants, making deafness-specific expertise a prerequisite for ascribing phenotypic consequences to genetic variants. Deafness-implicated variants are curated in the Deafness Variation Database (DVD) after classification by a genetic hearing loss expert panel and th...