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Influence of the exposed anatomic sites on the human in vivo percutaneous absorption of the amphiphilic 2-phenoxyethanolNARA Subscribed
Percutaneous penetration is an important human exposure route, but it is influenced by multiple factors and can vary greatly between different substances and exposure conditions. Furthermore, skin characteristics such as thickness of different anatomic sites may have an effect on percutaneous absorption. Despite a potential relevance for safety measures, little is yet known for occupationally relevant skin sites, like hands. W...
Dermal penetration of 2-phenoxyethanol in humans: in vivo metabolism and toxicokineticsNARA Subscribed
2-Phenoxyethanol (PhE) is an amphiphilic organic compound frequently used as a broad-spectrum preservative in cosmetic products and other consumer goods. PhE is also used as a biocidal component in occupational settings. A previous volunteer study by our working group following oral exposure to PhE showed that PhE is almost completely taken up into the human body followed by an extensive metabolization and fast urinary elimina...
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer studyNARA Subscribed
2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot stud...
Global maps of soil temperatureNARA Subscribed
Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1‐km 2 r...
Where to begin? Defining national strategies for implementing the 2030 Agenda: the case of SwitzerlandNARA Subscribed
Five years after adoption of the 2030 Agenda, there is a general lack of progress in reaching its Sustainable Development Goals—be it on national, regional, or global scales. Scientists attribute this above all to insufficient understanding and addressing of interactions between goals and targets. This study aims to contribute to the methodological conceptualization of the 2030 Agenda’s implementation at the national level. To...
SoilTemp: A global database of near‐surface temperatureNARA Subscribed
Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long‐term average thermal conditions at coarse spatial resolutions only. Hence, many climate‐forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to...