Thomas Brunner results 40
· Newest (Page 1/2, per page 25)
Author: Thomas Brunner ×Clear All Filters
Search Results
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Metastasis-directed stereotactic radiotherapy in patients with breast cancer: results of an international multicenter cohort studyNARA Subscribed
Metastasis-directed therapy (MDT) for oligometastatic breast cancer (≤ 5 metastases) has shown little effect in specific scenarios of randomized trials. Therefore, we aimed to assess outcomes after metastasis-directed stereotactic radiotherapy (SRT) in various clinical scenarios. We conducted an international retrospective cohort study in thirteen centers including breast cancer patients receiving SRT to any metastatic site. O...
Establishment of the deuterium oxide dilution method as a new possibility for determining the transendothelial water permeabilityNARA Subscribed
Increase in transendothelial water permeability is an essential etiological factor in a variety of diseases like edema and shock. Despite the high clinical relevance, there has been no precise method to detect transendothelial water flow until now. The deuterium oxide (D 2 O) dilution method, already established for measuring transepithelial water transport, was used to precisely determine the transendothelial water permeabili...
Purpose of Review Forests support most global terrestrial biodiversity and contribute to the livelihood of billions of people, but these and other benefits are in jeopardy due to global change. This leads to questions, such as how to address the challenges of global change in forest management, given the lack of knowledge and deep uncertainty about future developments. In addition, many of the impediments to implement adaptati...
G × E interactions as a basis for toxicological uncertaintyNARA Subscribed
To transfer toxicological findings from model systems, e.g. animals, to humans, standardized safety factors are applied to account for intra-species and inter-species variabilities. An alternative approach would be to measure and model the actual compound-specific uncertainties. This biological concept assumes that all observed toxicities depend not only on the exposure situation (environment = E), but also on the genetic (G)...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Heart failure (HF) is one of the most complex chronic disorders with high prevalence, mainly due to the ageing population and better treatment of underlying diseases. Prevalence will continue to rise and is estimated to reach 3% of the population in Western countries by 2025. It is the most important cause of hospitalisation in subjects aged 65 years or more, resulting in high costs and major social impact. The current “one-si...
EPMA-World Congress 2015NARA Subscribed