Hypoalbuminemia (HA) is frequently observed in systemic inflammatory diseases and in liver disease. However, the influence of HA on the pharmacokinetics and toxicity of compounds with high plasma albumin binding remained insufficiently studied. The ‘ lack-of-delivery-concept ’ postulates that HA leads to less carrier mediated uptake of albumin bound substances into hepatocytes and to less glomerular filtration; in contrast, th...

Aim To develop a physiologically based model of the plant niche for use in species distribution modelling. Location Europe. Methods We link the Thornley transport resistance (TTR) model with functions which describe how the TTR’s model parameters are influenced by abiotic environmental factors. The TTR model considers how carbon and nutrient uptake, and the allocation of these assimilates, influence growth. We use indirect sta...

Ecology Letters (2012) Abstract Caribbean reef corals have declined precipitously since the 1980s due to regional episodes of bleaching, disease and algal overgrowth, but the extent of earlier degradation due to localised historical disturbances such as land clearing and overfishing remains unresolved. We analysed coral and molluscan fossil assemblages from reefs near Bocas del Toro, Panama to construct a timeline of ecologica...

Aim To assess the extent to which climate change might cause changes in potential natural vegetation (PNV) across Europe. Location Europe. Method We parameterized a generalized dynamic vegetation model (LPJ‐GUESS) for the most common European tree species, and, for the first time, modelled large‐scale vegetation dynamics using a process‐based model explicitly representing tree species, age cohorts, gap dynamics and biogeochemi...

Species–climate ‘envelope’ models are widely used to evaluate potential climate change impacts upon species and biodiversity. Previous studies have used a variety of methods to fit models making it difficult to assess relative model performance for different taxonomic groups, life forms or trophic levels. Here we use the same climatic data and modelling approach for 306 European species representing three major taxa (higher pl...