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Cyclooxygenase-dependent contribution to increased flow mediated dilatation following a week of repeated ischemic preconditioningNARA Subscribed
Purpose Ischemic preconditioning (IPC) and remote ischemic preconditioning (RIPC) independently enhance endothelial function and flow mediated dilation (FMD); yet the underlying mechanisms remain incompletely defined. This study investigated the contribution of cyclooxygenase (COX) dependent vasodilators to FMD before and after repeated IPC and RIPC. Methods 21 healthy participants underwent Radial artery FMD assessments befor...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Introduction Copperheads and cottonmouths are responsible for most snake envenomations in Louisiana. While the United States Food and Drug Administration has approved both Crotalidae polyvalent immune Fab (FabAV) and Crotalidae immune F(ab’) 2 (Fab2AV) for Agkistrodon envenomations, data is limited comparing their efficacies for this indication. Methods This is a retrospective study comparing FabAV to Fab2AV in the treatment o...
A Global Regionalisation of Tree Functional CapacityNARA Subscribed
Aim Understanding the global distribution of tree functional diversity is essential for predicting ecosystem responses to environmental change. Traditional biogeographic regionalisations classify ecosystems based on species composition and climate but overlook functional traits, which directly govern processes such as carbon storage, nutrient cycling and productivity. Here, we present the first global functional regionalisatio...
Stony coral tissue loss disease (SCTLD) has spread throughout Florida’s Coral Reef, causing extensive mortality of over 30 species of reef-building corals, and has rapidly spread to many other countries and territories throughout the Caribbean. Current treatments for SCTLD, including a proprietary paste mixed with the antibiotic amoxicillin, do not provide protection from future infections and may select for antibiotic-resista...
This study examines the wave climate and its influence on potential Longshore Sediment Transport (LST) along the Shippagan coast of the Gulf of St. Lawrence, eastern Canada. Using a combination of in-situ observations and ERA5 reanalysis data, the research evaluates both seasonal and annual variations in wave dynamics and sediment transport, with particular attention to the role of extreme weather events. The wave climate show...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Monitoring Terrestrial Ecosystem Resilience Using Earth Observation Data: Identifying Consensus and Limitations Across MetricsNARA Subscribed
Resilience is a key feature of ecosystem dynamics reflecting a system's ability to resist and recover from environmental perturbations. Slowing down in the rate of recovery has been used as an early‐warning signal for abrupt transitions. Recent advances in Earth observation (EO) vegetation data provide the capability to capture broad‐scale resilience patterns and identify regions experiencing resilience loss. However, the prol...