In this study, we investigate the effect of the availability of sites for heterogeneous nucleation on the microstructure of moderately to highly undercooled synthetic trachybasalts under anhydrous and hydrous (2 wt% H₂O) conditions. Experiments were performed at 400 MPa by cooling melts from 1300 °C to target temperatures of 1150 °C, 1100 °C, and 1050 °C, followed by isothermal holds of 5 or 30 min. In one experimental series,...

Many extreme hazardous events do not occur in isolation, but rather interact with other events, as they occur simultaneously, cascadingly, or consecutively. Hazard interrelations are critical components in hazard assessments in today’s complex and interconnected world. One event may directly or indirectly affect other hazard events through various types of spatiotemporal connections within the geophysical environment. These in...

Multiple myeloma is a blood cancer characterized by plasma cell proliferation and excessive production of monoclonal proteins, often leading to renal complications and other forms of organ damage. A set of nine immunoglobulin free light chain (FLC) samples purified from urine of multiple myeloma patients was subjected to sedimentation velocity analysis. Aim of the study was to track changes of the oligomerization state of each...

While antineoplastic therapies aim to specifically target cancer cells, they may also exert adverse effects on healthy tissues, like healthy hematopoietic stem and progenitor cells (HSPC), leading to hematotoxicity as a common side effect. Mesenchymal stromal cells (MSC) are a major component of the bone marrow (BM) microenvironment, regulating normal hematopoiesis, while their susceptibility to anticancer therapies and contri...

To develop new criteria to distinguish different crystal nucleation mechanisms in silicate melts, we performed crystallization experiments using a synthetic hydrous (2 wt% H 2 O) trachybasalt and combined three-dimensional information from synchrotron X-ray computed microtomography with two-dimensional mapping of crystallographic orientation relationships (CORs) using electron backscatter diffraction. Crystallization experimen...

Rutile inclusions in almandine-spessartine garnet from a peraluminous pegmatoid from the Moldanubian zone (Bohemian Massif, AT) show distinct changes in aspect ratio, shape preferred orientations (SPO) and crystallographic orientation relationships (COR) along the transition between microstructurally different growth zones in the garnet core and rim. For identification of the COR characteristics we pool specific CORs based on...

Epidemiological studies demonstrate an association between migraine and chronic kidney disease (CKD), while the genetic basis underlying the phenotypic association has not been investigated. We aimed to help avoid unnecessary interventions in individuals with migraine through the investigation of phenotypic and genetic relationships underlying migraine, CKD, and kidney function. We first evaluated phenotypic associations using...

Driven by climate change, marine biodiversity is undergoing a phase of rapid change that has proven to be even faster than changes observed in terrestrial ecosystems. Understanding how these changes in species composition will affect future marine life is crucial for conservation management, especially due to increasing demands for marine natural resources. Here, we analyse predictions of a multiparameter habitat suitability m...

Bat-associated hantaviruses have been detected in Asia, Africa and Europe. Recently, a novel hantavirus (Brno loanvirus, BRNV) was identified in common noctule bats ( Nyctalus noctula ) in the Czech Republic, but nothing is known about its geographical range and prevalence. The objective of this study was to evaluate the distribution and host specificity of BRNV by testing bats from neighbouring countries Germany, Austria and...

A new rich and diversified ostracode fauna from the Torkoz area (section Hassi Mouf South, Moroccan Anti-Atlas) is described and the ostracode distribution near the Early/Middle Devonian boundary is discussed. This ostracode fauna of a single limestone bed yields 32 taxa and is compared with the less-diversified ostracode fauna from an adjacent parallel section Hassi Mouf South as well as with a published conodont-bearing samp...

Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT 3 receptor family. 5-HT 3 Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular. Moreover, 5-HT 3 R antagonists are beneficial in the treatment of diarrhea predominant IBS (IBS-D). We previously reported on functionally relevant...