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Purpose Exercise can reduce C-reactive protein (CRP), but heterogeneity exists and it is unclear whether exercise-induced weight compensation occurs or relates to CRP change. We examined whether compensation occurs in adults with elevated CRP during exercise and whether compensation and compensatory behaviours are associated with CRP change. Methods In this 4-month randomised controlled trial, 124 sedentary adults with elevate...
Assessment of the macroalgal genetic resources maintained in European germplasm banksNARA Subscribed
Germplasm banks are important for preserving genetic diversity, yet the availability and long-term maintenance of macroalgal strains in germplasm banks is currently limited in European collections. To support future food security, restoration efforts, and biotechnological innovation, a strategy was recently developed for the long-term preservation of macroalgal genetic diversity. A foundational step in this effort is to assess...
Evaluating a structured expert elicitation approach for adaptive conservation management based on lessons from five years in practiceNARA Subscribed
Adaptive management of threatened species relies on having ex ante estimates of species’ responses to different interventions. Structured expert elicitation is often used to generate these estimates, but comparisons of these expert‐predicted outcomes with observed results are rare. This study aims to evaluate the utility of expert elicitation for adaptive management in the New South Wales Saving our Species program in Australi...
Calibration of the species threat abatement and restoration metric's threat abatement component in a Costa Rican landscapeNARA Subscribed
Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species. STAR scores quantify the potential contribution of actions to abate threats and restore habitat to reduce species extinction risk in a particular place and can...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Physical drivers of historical deoxygenation events and capacity for reef recovery in a fringing reef systemNARA Subscribed
Deoxygenation events threaten coral reefs as they can result in biodiversity loss and are expected to occur more frequently with increasing sea temperatures and eutrophication. Multiple deoxygenation events have occurred at Bill’s Bay, a semi-enclosed lagoon within the UNESCO World Heritage-listed Ningaloo Marine Park, and have been associated with significant ecosystem impacts, including fish kills and coral mortality. Althou...
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityNARA Subscribed
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between telomere length and aging-related diseases. Therefore, telomeres are considered to be one of the biomarkers of aging, and increasing or maintaining telomere length may contribute to heal...