Experimental designs in dose response experiments often use simple setups where the dose levels are increased by a fixed factor on the log scale. More efficient or even formally optimal experimental designs exist for this context, but these are often unpopular among applied scientists as they usually depend on the true value of some of the parameters and also frequently propose using only a small number of distinct dose levels...

In vitro experiments have shown that the E2 protein of human papillomaviruses (HPV) binds to the upstream regulatory region (URR) of the viral genome and modulates transcription. Additionally, it seems to be a necessary component for viral DNA replication together with E1. We have developed a transgenic mouse model containing the URR region of the low-risk virus HPV11 that regulates the expression of the lacZ reporter gene. Mo...