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Springer Nature1
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Plant Cell Reports1
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20211
Tim Leykauf results 1 · Newest (Page 1/1, per page 25)
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RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide contentNARA Subscribed
Plant Cell Reports · 2021 · Vol. 40 · Issue 9 · Springer
Jan Klein; Elisa Horn; Mona Ernst; Tim Leykauf; Tamara Leupold; Maja Dorfner; Laura Wolf; Anastasiia Ignatova; Wolfgang Kreis; Jennifer Munkert
Key message Studying RNAi-mediated DlP5βR1 and DlP5βR2 knockdown shoot culture lines of Digitalis lanata, we here provide direct evidence for the participation of PRISEs (progesterone 5β-reductase/iridoid synthase-like enzymes) in 5β-cardenolide formation. Abstract Progesterone 5β-reductases (P5βR) are assumed to catalyze the reduction of progesterone to 5β-pregnane-3,20-dione, which is a crucial step in the biosynthesis of th...
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