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Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicitiesNARA Subscribed
APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...
Contrasting life‐history strategies of three sympatric icefish species in the northern Scotia SeaNARA Subscribed
Comprehending a species' life‐history strategies is crucial to inform effective conservation efforts. Commercial fishing impacts icefish (family: Channichthyidae) in the Scotia Sea, but detailed information on species‐specific life histories remains largely unknown. In this study, the demographic characteristics of mackerel icefish ( Champsocephalus gunnari ), blackfin icefish ( Chaenocephalus aceratus ) and South Georgia icef...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
To effectively manage biological assemblages, a sound knowledge of the biodiversity is essential. The Southern Ocean shelf benthic assemblages are typically comprised of species, the names of which are shared across the huge expanse of the region, indicating large population sizes and good connectivity, inferring resilience. This is despite two decades of studies identifying cryptic or unrecognised species in many benthic grou...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α‐diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ‐diversity), either due to reduced β‐diversity amplifying diversity loss or increased β‐diversity dampening diversity loss. Additionally, studies often focus on taxo...
Genome‐wide population affinities and signatures of adaptation in hydruntines, sussemiones and Asian wild assesNARA Subscribed
The extremely rich palaeontological record of the horse family, also known as equids, has provided many examples of macroevolutionary change over the last ~55 Mya. This family is also one of the most documented at the palaeogenomic level, with hundreds of ancient genomes sequenced. While these data have advanced understanding of the domestication history of horses and donkeys, the palaeogenomic record of other equids remains l...
The fundamental goal of a rare plant translocation is to create self‐sustaining populations with the evolutionary resilience to persist in the long term. Yet, most plant translocation syntheses focus on a few factors influencing short‐term benchmarks of success (e.g., survival and reproduction). Short‐term benchmarks can be misleading when trying to infer future growth and viability because the factors that promote establishme...
2022 marked the third consecutive La Niña and extended the longest consecutive stretch of negative Oceanic Niño Index since 1998-2001. While physical and biological conditions in winter and spring largely adhered to prior La Niña conditions, summer and fall were very different. Similar to past La Niña events, in winter and spring coastal upwelling was either average or above average, temperature average or below average, salin...
The global decline of terrestrial species is largely due to the degradation, loss and fragmentation of their habitats. The conversion of natural ecosystems for cropland, rangeland, forest products and human infrastructure are the primary causes of habitat deterioration. Due to the paucity of data on the past distribution of species and the scarcity of fine‐scale habitat conversion maps, however, accurate assessment of the rece...