Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...

Chytrids (phylum Chytridiomycota ) are zoosporic fungi that play key roles as parasites of aquatic microorganisms, yet they are understudied and genomic resources for algal-infecting chytrids remain scarce. Here, we present the first comparative genomic analysis of multiple isolates of a single chytrid species (order Rhizophydiales ) infecting the cyanobacterium Planktothrix agardhii . Isolates were collected from Sandusky Bay...

As climate change and its impacts have become more pronounced, financial firms, investors, and regulatory supervisors are increasingly seeking to understand financial climate risks. One frequently mentioned barrier to using global change science is that information coming from global change scenarios and models may not match the needs of financial users. For example, there is often a spatial and temporal mismatch between scena...

The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...

The Ulleung Basin (UB), in the East Sea (Japan Sea) hosts a long-term ocean monitoring station with a time-series sediment trap. We present new 1-year sinking particle fluxes, along with organic (radiocarbon) and inorganic (detrital neodymium; ϵNd -detrital ) isotopic compositions of sinking particles and surface sediments in order to constrain lateral particle advection. The εNd -detrital values of the Korean Peninsula and th...

Ecosystem metabolism (e.g., gross primary production [GPP], respiration [R], and net ecosystem production) integrates the activity of aerobic organisms and is an indicator of environmental change. Microplastics (i.e., particles 1–5 mm) are widespread in freshwater ecosystems and are colonized by biofilms and other organisms. However, microplastics' effects on ecosystem‐level processes including metabolism or other gas fluxes i...

Clinical chemistry retains its position as a cornerstone of toxicological assessment, yet inter-laboratory variability in baseline values remains a challenge for the integration and interpretation of multisite datasets. This study leveraged a publicly available clinical chemistry database to assess the impact of inter-laboratory variability in response to hydrazine-induced steatosis. Seventeen clinical chemistry and physico-ch...