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Assessing carcinogenic outcomes following short-term exposure to potentially DNA-reactive drugs: Are available data sufficient to inform risk assessment?NARA Subscribed
Regulatory Toxicology and Pharmacology · 2026 · Vol. 165 · Academic Press
Dayton M. Petibone; Jennifer M. Shemansky; Timothy W. Robison; Aisar H. Atrakchi; Robert H. Heflich
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Germline mutagenicity of molnupiravir and its active form, β-d-N4-hydroxycytidine, in Caenorhabditis elegans evaluated using whole-genome sequencingNARA Subscribed
Toxicology Letters · 2025 · Vol. 409 · Elsevier
Li Xia; Jian Yan; Ying Chen; Timothy W. Robison; Tao Chen
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutationsNARA Subscribed
Mutation Research - Genetic Toxicology and Environmental Mutagenesis · 2024 · Vol. 897 · Elsevier
Yiying Wang; Yuan Le; Kelly L. Harris; Ying Chen; Xilin Li; Jennifer Faske; Rebecca A. Wynne; Roberta A. Mittelstaedt; Xuefei Cao; Jaime Miranda-Colon; Lana Elkins; Levan Muskhelishvili; Kelly Davis; Nan Mei; Wei Sun; Timothy W. Robison; Robert H. Heflich; Barbara L. Parsons
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencingNARA Subscribed
Archives of Toxicology · 2024 · Vol. 98 · Issue 6 · Springer
Ji-Eun Seo; Yuan Le; Javier Revollo; Jaime Miranda-Colon; Hannah Xu; Page McKinzie; Nan Mei; Tao Chen; Robert H. Heflich; Tong Zhou; Timothy Robison; Jessica A. Bonzo; Xiaoqing Guo
Human liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the present study, we have investigated expanding the genotoxicity endpoints evaluated in HepaRG cells by detecting mutagenesis using two error-corrected next generation sequencing (ecNGS) technologies, Duplex Sequencing (DS)...
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Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencingNARA Subscribed
Archives of Toxicology · 2023 · Vol. 97 · Issue 8 · Springer
Hua Du; Bohu Pan; Alexander W. Alund; Jian Yan; Ying Chen; Timothy W. Robison; Tao Chen
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A molten salt test loop for component and instrumentation testingNARA Subscribed
Annals of Nuclear Energy · 2023 · Vol. 186 · Pergamon
T.L. Head; Allison M. Berry; Keaton J. Brewster; Robert L. Brown; Hailey N. Burden; Reuben Byrd; Timothy Doty; Jess Dowdy; Kameron A. Hill; R.A. Jinkerson; Timothy J. Kennedy; Ronald C. Laehn; Dakotah Martinez; Samuel L. Mulder; Charles Onstead; Kim L. Pamplin; Dylan C. Pfeifer; Michael B. Ranger; Aaron D. Robison; Nathaniel T. Rowlands; Raymond E. Smith; Matthew T. Steele; R.S. Towell; Travis Towell; Olive Tuyishimire; T.S. Watson
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Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell linesNARA Subscribed
Archives of Toxicology · 2020 · Vol. 94 · Issue 6 · Springer
Ji-Eun Seo; Qiangen Wu; Matthew Bryant; Lijun Ren; Qiang Shi; Timothy W. Robison; Nan Mei; Mugimane G. Manjanatha; Xiaoqing Guo
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Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assayNARA Subscribed
Archives of Toxicology · 2019 · Vol. 93 · Issue 5 · Springer
Ji-Eun Seo; Volodymyr Tryndyak; Qiangen Wu; Kostiantyn Dreval; Igor Pogribny; Matthew Bryant; Tong Zhou; Timothy W. Robison; Nan Mei; Xiaoqing Guo
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Islands of Ice: Influence of Free-Drifting Antarctic Icebergs on Pelagic Marine EcosystemsOA Marine
Oceanography · 2012 · Vol. 25 · Issue 3 · The Oceanography Society
Maria Vernet; Kenneth Smith; Adrián Cefarelli; John Helly; Ronald Kaufmann; Hai Lin; David Long; Alison Murray; Bruce Robison; Henry Ruhl; Timothy Shaw; Alana Sherman; Janet Sprintall
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