APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...

Chytrids (phylum Chytridiomycota ) are zoosporic fungi that play key roles as parasites of aquatic microorganisms, yet they are understudied and genomic resources for algal-infecting chytrids remain scarce. Here, we present the first comparative genomic analysis of multiple isolates of a single chytrid species (order Rhizophydiales ) infecting the cyanobacterium Planktothrix agardhii . Isolates were collected from Sandusky Bay...

Engineering crop plants with the biological nitrogen fixation pathway is a longstanding goal of modern agriculture. Dinitrogenase reductase (NifH) is a critical component of the biological nitrogen fixation pathway, with multiple roles in metal cofactor assembly and catalysis. This enzyme must be folded correctly as a soluble homodimer and loaded with the [4Fe-4S] metallocluster for function. Previous studies have found that K...

Purpose Cerebral palsy (CP) is typically associated with abnormal gait that may alter knee joint loading and accelerate joint degeneration. We developed an integrated musculoskeletal-finite element (MSK-FE) framework to quantify differences in knee joint biomechanics between children with CP and typically developing (TD) peers. Methods Gait data from 13 children (TD, n = 5; hemiplegia [HP], n = 4; diplegia [DP], n = 4) were an...

The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...