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Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicitiesNARA Subscribed
APOE ’s ε4 haplotype ( APOE4 ) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4 ’s effect is critical to understanding LOAD. This is especially important as APOE4 odds ratios (OR) vary across racial and ethnic (R/E) groups. We analyzed the APOE4 -LOAD association in 3,196 East Asian, 31,105 non-Hispanic White (White), 1,646 Hispanic and Latino (Hispanic), and 6,068...
Intercropping alters rhizosphere chemistry but not early root distribution in a low phosphorus fieldNARA Subscribed
Summary Background and aims Intercropping represents an opportunity to diversify root system architectures and rhizosphere processes, optimising soil resource use, especially for nutrients with low availability. This study assessed belowground interactions in faba bean ( Vicia faba ) and barley ( Hordeum vulgare ) intercropping under marginal field conditions during early growth. Methods Root distribution was measured to 40 cm...
Watershed land cover predicts the abundance of macroplastic and other anthropogenic litter in streamsNARA Subscribed
Macroplastic and other types of macroscopic anthropogenic litter (AL; trash, particles > 5 mm) are pervasive across ecosystems, persistent in the environment, increasing in abundance, and can degrade into microplastics (particles 2 and 0.011–87.482 g/m 2 . Watershed impervious surface area and urban cover were significant predictors of AL by count (pseudo R 2 = 0.418), likely due to greater numbers of AL sources and enhanced c...
Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee LoadingNARA Subscribed
Purpose To investigate temporal evolution of cartilage strain and relaxometry following ACL reconstruction, and examine associations between MRI metrics, pain, and knee loading patterns during gait as potential early markers of cartilage degeneration. Methods Twenty-five participants (15 female, 10 male; mean age 25.6 years) undergoing ACL reconstruction completed MRI assessments at 6 and 12 month post-surgery, including displ...
Considering Opportunities and Challenges When Implementing the Model Master File Framework – a Meeting ReportNARA Subscribed
Graphical Abstract
Pediatric Exposures Associated with Caffeine Energy Products Reported to United States Poison Centers, 2011–2023NARA Subscribed
Introduction This study investigated the characteristics and trends of pediatric exposures to caffeine energy products reported to US poison centers Methods National Poison Data System data for caffeine energy product single-substance exposures during 2011–2023 among individuals < 20 years old were analyzed. Results There were 32,482 caffeine energy product exposures reported to US poison centers with a 17.3% exposure rate inc...
Dominance and rarity in tree communities across the globe: Patterns, predictors and threatsNARA Subscribed
Aim Ecological and anthropogenic factors shift the abundances of dominant and rare tree species within local forest communities, thus affecting species composition and ecosystem functioning. To inform forest and conservation management it is important to understand the drivers of dominance and rarity in local tree communities. We answer the following research questions: (1) What are the patterns of dominance and rarity in tree...