Ictalurid herpesvirus 1 (IcHV1) is the most significant viral agent in U.S. catfish aquaculture. Little is known regarding the genetic stability and antigenic variability of IcHV1. Herein, the genetic and antigenic diversity of IcHV1 field isolates was assessed by restriction fragment length polymorphism (RFLP) analysis and serum neutralization assays. RFLP analysis identified two distinct genotypes (IcHV1A and IcHV1B), both d...

Immunogenicity assessment of Adeno-Associated Virus (AAV) vectors is a critical part of gene therapy drug development. Whether the assays are used for inclusion/exclusion criteria or to monitor the safety and efficacy of the gene therapy, they are critical bioanalytical assessments. While total anti-AAV assays are perceived as easier to develop and implement than neutralizing anti-AAV assays, the gene therapy field is still na...

Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. A team of experts within the American Association of Pharmaceutical Scientists’ Therapeutic Product Immunogenicity Community across industry and the Food and Drug Administration address...

Seeing and conserving wildlife are among the most important management objectives for nonindustrial private landowners in the eastern United States. Landowners want profitable timber harvests but also want to know how harvesting will affect their wildlife. The study examined associations between stand characteristics and wildlife abundance on 40 stands receiving different logging intensities in northeastern Pennsylvania and fo...

The relative abundance and species richness of herpetofauna was investigated to assess the impact of recent logging operations in 47 forest stands in northeastern Pennsylvania during 1996 and 1997. Stands including nonindustrial private forestlands and public lands that have received some type of harvesting within the last 8 yr ranged from near complete overstory tree cover to complete removal of overstory cover. Stands includ...