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The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Out‐of‐Africa: Origin of the Disjunct Distribution of Paleotropical Eneopterinae Crickets (Gryllidae, Xenogryllini)NARA Subscribed
Many groups of terrestrial plants and animals display a disjunct distribution pattern in the Paleotropics, being found almost exclusively in tropical Africa and Asia. The origin of such a pattern may be manifold, particularly for older lineages where plate tectonics potentially played an important role. Several potential colonisation routes may have been involved in dispersal events between the Afrotropics and tropical Asia, n...
Validation of a Göttingen Minipig Gene Therapy Biodistribution Assay for AVGN7 Using Droplet Digital Polymerase Chain ReactionNARA Subscribed
Minipig models are rapidly gaining popularity in gene therapy preclinical studies. This includes biodistribution studies that are required by regulatory agencies, but are poorly described in the literature. This is particularly true for ddPCR assays with enhanced sensitivity over traditional “real-time” PCR. We, therefore, validated a novel duplex ddPCR assay for quantifying AVGN7, an AAV gene therapeutic featuring a codon-opt...
The Cost of Antivenom: A Cost Minimization Study using the North American Snakebite RegistryNARA Subscribed
Envenomation is a global health issue, with over 9,000 encounters managed in the United States yearly. The introduction of immunoglobulin fragment antivenom has reduced the risk of hypersensitivity. This study compares treatment costs of crotaline envenomation using the Fab and F(ab’) 2 antivenoms as reported to the North American Snakebite Registry (NASBR), a nationwide surveillance tool. Methods This was a retrospective anal...
Increased Mineral‐Associated Organic Carbon and Persistent Molecules in Allochthonous Blue Carbon EcosystemsNARA Subscribed
Coastal wetlands contain very large carbon (C) stocks—termed as blue C—and their management has emerged as a promising nature‐based solution for climate adaptation and mitigation. The interactions among sources, pools, and molecular compositions of soil organic C (SOC) within blue C ecosystems (BCEs) remain elusive. Here, we explore these interactions along an 18,000 km long coastal line of salt marshes, mangroves, and seagras...
Background Contrast-induced neurotoxicity (CIN) is a recognised complication of endovascular procedures and has been increasingly observed in recent years. Amongst other clinical gaps, the precise incidence of CIN is unclear, particularly following intracranial interventional procedures. Methods A retrospective study of consecutive patients undergoing elective endovascular treatment of unruptured intracranial aneurysms (UIAs)...
Biogenic silica dynamics in coastal wetland sediments: A key driver of silicon and carbon biogeochemical cyclingNARA Subscribed
Biogenic silica (biogenic Si) is a bioactive component crucial for the biogeochemical cycling of Si in terrestrial and aquatic ecosystems. Its formation and dissolution dynamics are intricately linked to carbon (C) cycling. However, knowledge about the source, composition, and factors controlling the distribution of biogenic Si in coastal wetland sedimentary environments is still limited. To address this lack of knowledge, we...