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Springer Nature1
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Toxicological Research1
Publication Year
20241
Turki Alkully results 1 · Newest (Page 1/1, per page 25)
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Author: Turki Alkully ×Clear All Filters
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Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in ratsNARA Subscribed
Toxicological Research · 2024 · Vol. 40 · Issue 1 · Springer
Marwa Monier Mahmoud Refaie; Sayed Shehata; Maram El-Hussieny; Michael Atef Fawzy; Nagwa Zenhom Mustafa Ahmed; Heba Marey; Asmaa Mohammed Hishmat; Turki Alkully; Eman Shaaban Mahmoud Abd El Rahman
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-FU is complicated with serious cardiotoxic effects and the safe use becomes an urgent task in cardio-oncology. Till now, there are no studies discussed the role of empagliflozin (EMP) against 5-FU cardiotoxicity. Thus, we investigated this effect and the involved mechanisms in 5-FU induced heart injury. For...
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