Summary The clpC operon is known to regulate several processes such as genetic competence, protein degradation and stress survival in bacteria. Here, we describe the role of clpC operon in B acillus anthracis . We generated knockout strains of the clpC operon genes to investigate the impact of CtsR , McsA , McsB and ClpC deletion on essential processes of B . anthracis. We observed that growth, cell division, sporulation and g...

Summary The alternative sigma factor σ B is the master regulator of the general stress regulon that comprises approximately 200 genes whose products confer a comprehensive stress resistance to Bacillus subtilis . The characterization of MgsR ( m odulator of the g eneral s tress r esponse) revealed that the activation and induction of σ B are a prerequisite but not sufficient for a full expression of all general stress genes. M...

Summary The general stress response and the decision‐making processes of sporulation initiation are interconnected pathways in the regulatory network of Bacillus subtilis . In a previous study we provided evidence for a mechanism capable of impairing sporulation by σ B ‐dependent induction of spo0E , encoding a phosphatase specifically inactivating the sporulation master regulator Spo0A∼P. Here we show that the σ B promoter (P...