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NARA Subscribed1
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Springer Nature1
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Journal of Molecular Medicine1
Publication Year
20251
Ulrich L. M. Eisel results 1 · Newest (Page 1/1, per page 25)
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Author: Ulrich L. M. Eisel ×Clear All Filters
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Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone modelNARA Subscribed
Journal of Molecular Medicine · 2025 · Vol. 103 · Issue 7 · Springer
Valentina Pegoretti; Ate Boerema; Kim Kats; Juan M. Dafauce Garcia; Roman Fischer; Roland E. Kontermann; Klaus Pfizenmaier; Jon D. Laman; Ulrich L. M. Eisel; Wia Baron
The development of therapeutics that enhances the regeneration of myelin sheaths following demyelination is predicted to prevent neurodegeneration. A promising target to enhance remyelination is the immunomodulatory cytokine tumor necrosis factor alpha (TNFα) and its receptors TNFR1 and TNFR2. TNFR2 on oligodendrocyte lineage cells and microglia coordinates different protective functions, such as proliferation of oligodendrocy...
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