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Multi-risk assessment in a historical cityNARA Subscribed
Natural hazards pose a significant threat to historical cities which have an authentic and universal value for mankind. This study aims at codifying a multi-risk workflow for seismic and flood hazards, for site-scale applications in historical cities, which provides the Average Annual Loss for buildings within a coherent multi-exposure and multi-vulnerability framework. The proposed methodology includes a multi-risk correlatio...
Metabolic Switching of Cultured Mesenchymal Stem Cells Creates Super Mitochondria in Rescuing Ischemic NeuronsNARA Subscribed
Transfer of healthy mitochondria from mesenchymal stem cells (MSCs) to ischemic neurons represents a potent stroke therapeutic. MSCs were grown under ambient conditions (nMSCs) or a metabolic switching paradigm by alternating galactose and glucose in medium (sMSCs) and then assayed for oxygen consumption rates using the Seahorse technology. Subsequently, primary neurons were subjected to oxygen glucose deprivation (OGD) and th...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
The Toxicology Investigators Consortium 2020 Annual ReportNARA Subscribed
North American Brant: effects of changes in habitat and climate on population dynamicsNARA Subscribed
We describe the importance of key habitats used by four nesting populations of nearctic brant ( Branta bernicla ) and discuss the potential relationship between changes in these habitats and population dynamics of brant. Nearctic brant, in contrast to most geese, rely on marine habitats and native intertidal plants during the non‐breeding season, particularly the seagrass, Zostera , and the macroalgae, Ulva . Atlantic and East...
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