V. Kelly results 161
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Integrating genomic medicine into primary care –examining perceptions of community advisory board membersNARA Subscribed
The Alabama Genomic Health Initiative (AGHI), funded by the state of Alabama, aims to provide genomic testing, interpretation, and counseling free of charge to Alabama residents. A 14-member Community Advisory Board (CAB) was convened in 2021 to provide community insight on integrating genomic medicine into clinical care and assessing future perspectives. The CAB was comprised of members from diverse ethnic backgrounds and rep...
Antibiotics cause significant gut microbiome dysbiosis, particularly when administered orally. This contributes to antimicrobial resistance (AMR) and is associated with myriad health conditions. Novel drug delivery strategies that minimize gut exposure while maintaining therapeutic efficacy are urgently needed. This study aimed to evaluate whether a novel transdermal system could reduce gut microbiome disruption compared to or...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Objective and design This study investigated the antinociceptive potential and mechanisms of Protectin DX (PDX) in a KO 2 -induced inflammatory pain. Treatment Male mice received PDX (1, 3, or 10 ng) or vehicle (0.7% ethanol in sterile saline) intraperitoneally (i.p.), 1 h before KO 2 (30 µg intraplantar [i.pl.] or 1 mg [i.p.]). Methods Upon KO 2 injection, evoked (mechanical and thermal hyperalgesia, and mechanical allodynia)...
Holocene patterns of peat accumulation in Peruvian AmazoniaNARA Subscribed
Unprecedented Burning in Tropical Peatlands During the 20th Century Compared to the Previous Two MillenniaNARA Subscribed
Tropical peatland wildfire incidence has risen in recent decades, driven by drainage for land use and intensified by severe droughts with global climate change. These disturbances have altered vegetation structure, disrupted ecosystem functioning, and increased carbon emissions, particularly in Southeast Asia. However, the long‐term history and characteristics of wildfires in tropical peatlands remain largely unknown. Here, we...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Intranasal delivery of engineered anti-SARS-CoV-2 extracellular vesicles therapeutically represses lung infection and inflammationNARA Subscribed
Extracellular vesicles (EVs) are amenable to genetic engineering in that EVs can be endowed with surface armaments that can directly bind to target molecules or receptors. We previously developed HEK293 cell-derived EVs that contain a novel fusion tetraspanin protein, CD63, embedded within a highly conserved anti-SARS-CoV-2 nanobody, VHH72. These anti-SARS-CoV-2-enriched EVs bind SARS-CoV-2 spike protein and can functionally n...
The spatial distribution of calving habitat of humpback whales ( Megaptera novaeangliae ) has been understood as confined to warm, low latitude waters. The need for females to reach such habitats to give birth and provide early maternal care underpins the dominant theories on humpback whale migration. In Australia, calving habitat is accepted to be distributed no further south than 23-28°S and is generally presumed not to occu...